It has been an honor to be the editor of the second edition-first major revision in 30 years-of Netter's Respiratory System. The changes that have occurred over the past 3 decades in pulmonary medicine have been profound. The challenge of editing this edition has therefore been to include these updates while at the same time preserving the unique nature and artistic beauty of Netter's classic depiction of human health and disease. In addition to ensuring the accuracy and relevance of the timeless topics of anatomy and physiology, we have significantly revised the sections on airways, parenchymal and pleural diseases, lung cancer, infectious diseases, thromboembolic disease, inhalational diseases, acute respiratory distress syndrome, pharmacotherapy, radiology, mechanical ventilation, and trauma and surgery. New sections have been created on pulmonary immunology, pulmonary hypertension, lung manifestations of systemic disease, sleep medicine, exhaled breath analysis, endobronchial ultra-sound, video-assist...