黄皮酰胺的化学和生物学活性（The Chemistry and Biological Activ）

Overview: Recent Advances in the Study of (-)Clausenamide on Chemistry,

Biological Activities and Mechanism of Action 1

The Synthesis of Clausenamide Family Natural Products and Analogues 14

Pharmacological Activity of Clausenamide as A Chiral Drug 33

Neuroprotection of (-)Clausenamide via Inhibiting Tau Hyperphosphorylation

and Preserving Microtubule Structure 49

Synaptic Pharmacology of Clausenamide 64

Two Forms of Long-term Potentiation Induced by (-)Clausenamide and Rgl 73

The Nootropic Mechanism of (-)Clausenamide 80

Mechanism of (-)Clausenamide Induced Calcium Transient in Primary Culture

of Rat Cortical Neurons 85

(-)Clausenamide Enhances the Synaptic Plasticity through Gasotransmitters 96

Antiapoptotic Effect of (-)Clausenamide and its Mechanisms of Action 107

The Signal Transduction Pathway of (-)Clausenamide on Activation of

Learning and Memory 114

Pharmacokinetics and Metabolism of Clausenamide Enantiomers 119

Metabolic Transformation of Clausenamide 142

Preclinical Safety Evaluation and General Pharmacology of (-)Clausenamide 148

Optical Separation and Quality Research of Clausenamide Enantiomers 157

Abstracts in English and Chinese 173